A diabetic woman who was asked recently about autonomous glucose management systems responded that she wasn’t the least bit interested, didn’t trust them, and preferred being in control. As healthcare devices and systems involve increasing levels of automation, trust is a key factor in determining patient acceptance and effective use. Automated technology promises to improve healthcare, but only if used appropriately. If not trusted, it is unlikely to be used; if over-trusted, it may be used improperly (Lee & See 2004). Designing to achieve the right level of trust requires understanding how trust develops in the complex environment of real situations and use (Norman & Stappers 2016). Designing effective solutions necessitates appreciating the perspectives of all stakeholders: patients, their families, caregivers, researchers, and industry.